Smallpox Killed 300 million People in the Last Century Before Eradication

Superfact 24: Smallpox killed 300 million people in the 20th century. However, there have been no naturally occurring cases of smallpox since 1977, and the world was declared free of smallpox on May 8, 1980, by the 33rd World Health Assembly.

Smallpox vaccine Stock Illustration ID: 1782022109 by Novikov Aleksey

300 million people is an astonishing number. It is six times the 50 million people who died from the Spanish flu. It is about four times as many people as the 70 to 85 million people who died in World War II. It is close to the entire current population of the United States. That’s how many people died from this very dangerous disease. It was eradicated by a vaccination campaign.

I think this fact qualify as a super-fact, first of all because of the astonishingly huge number of deaths but also for the fact that it is gone. It is hard to believe that this happened. It is hard to believe that the world has changed so drastically for the better. It is a shocking but true fact. Thanks to the vaccination campaign we are living in a much better world.

This world map shows when smallpox was eradicated from different countries. The source is Our World in Data, originally Fenner et al. at CDC.

What is Smallpox?

Smallpox is an infectious disease caused by the variola virus<<Link-1>>. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980.  The disease begins with fever and vomiting followed by the formation of ulcers in the mouth and a skin rash that later turns into fluid filled blisters with a dent in the middle. These blisters get scabbed and leave scars. The death rate was about 30%.

Child with smallpox in Bangladesh 1975. Wikimedia commons photo by CDC/James Hicks.

The Eradication of Smallpox and Vaccines

The smallpox vaccine has a long history that begin in China where smallpox inoculation had existed long before it did in Europe. In 1796 the English physician Edward Jenner demonstrated the effectiveness of cowpox to protect humans from smallpox. Soon after several countries enacted mandatory vaccinations.

In 1807, Bavaria became the first country in the world to introduce compulsory vaccinations. In 1958 the World Health Assembly was called upon to eradicate smallpox. At this point 2 million people still died from smallpox every year. In 1967 the World Health Organization intensified the global smallpox eradication. As mentioned, smallpox was eradicated at the end of the 1970’s.

In 1998 & 2002 vaccination was dealt a blow by the Wakefield studies claiming that the MMR vaccine caused autism. Even though the studies were debunked, and several later studies showed no link between the MMR vaccines and autism, the fear of vaccines began to spread.  

For example, in 2024 the American Veterinary Medical Association reported 37% of the dog owners surveyed believe canine vaccination could cause autism in their dogs. Not only is there no link between vaccines and autism, but technically speaking, dogs cannot be autistic as the condition is unique to humans. Unfortunately, the unnecessary fear of vaccines causing autism seems to only be getting worse.


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Are you vaccinated against smallpox?