The goal of this blog is to create a long list of facts that are important, not trivia, and that are known to be true yet are either disputed by large segments of the public or highly surprising or misunderstood by many.
Category: Biology
Important but surprising facts relating to Biology
Superfact 24: Smallpox killed 300 million people in the 20th century. However, there have been no naturally occurring cases of smallpox since 1977, and the world was declared free of smallpox on May 8, 1980, by the 33rd World Health Assembly.
Smallpox vaccine Stock Illustration ID: 1782022109 by Novikov Aleksey
300 million people is an astonishing number. It is six times the 50 million people who died from the Spanish flu. It is about four times as many people as the 70 to 85 million people who died in World War II. It is close to the entire current population of the United States. That’s how many people died from this very dangerous disease. It was eradicated by a vaccination campaign.
I think this fact qualify as a super-fact, first of all because of the astonishingly huge number of deaths but also for the fact that it is gone. It is hard to believe that this happened. It is hard to believe that the world has changed so drastically for the better. It is a shocking but true fact. Thanks to the vaccination campaign we are living in a much better world.
This world map shows when smallpox was eradicated from different countries. The source is Our World in Data, originally Fenner et al. at CDC.
What is Smallpox?
Smallpox is an infectious disease caused by the variola virus<<Link-1>>. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980. The disease begins with fever and vomiting followed by the formation of ulcers in the mouth and a skin rash that later turns into fluid filled blisters with a dent in the middle. These blisters get scabbed and leave scars. The death rate was about 30%.
Child with smallpox in Bangladesh 1975. Wikimedia commons photo by CDC/James Hicks.
The Eradication of Smallpox and Vaccines
The smallpox vaccine has a long history that begin in China where smallpox inoculation had existed long before it did in Europe. In 1796 the English physician Edward Jenner demonstrated the effectiveness of cowpox to protect humans from smallpox. Soon after several countries enacted mandatory vaccinations.
In 1807, Bavaria became the first country in the world to introduce compulsory vaccinations. In 1958 the World Health Assembly was called upon to eradicate smallpox. At this point 2 million people still died from smallpox every year. In 1967 the World Health Organization intensified the global smallpox eradication. As mentioned, smallpox was eradicated at the end of the 1970’s.
In 1998 & 2002 vaccination was dealt a blow by the Wakefield studies claiming that the MMR vaccine caused autism. Even though the studies were debunked, and several later studies showed no link between the MMR vaccines and autism, the fear of vaccines began to spread.
For example, in 2024 the American Veterinary Medical Association reported 37% of the dog owners surveyed believe canine vaccination could cause autism in their dogs. Not only is there no link between vaccines and autism, but technically speaking, dogs cannot be autistic as the condition is unique to humans. Unfortunately, the unnecessary fear of vaccines causing autism seems to only be getting worse.
The goal of this blog is to create a list of what I call Newstrade. Important facts that we know to be true and yet they are surprising, shocking or disputed among non-experts. Special facts that any well-informed person should know.
Paperback – $18.95 on Amazon – future release March 25, 2025.
Hardcover – Publisher : Princeton University Press; First Edition (September 12, 2023), ISBN-10 : 0691177295, ISBN-13 : 978-0691177298, 240 pages, item weight : 1 pounds, dimensions : 5.75 x 1 x 8.5 inches, it costs $18.95 on Amazon. Click here to order it from Amazon.com.
Kindle – Publisher : Princeton University Press (September 12, 2023), ASIN : B0C5SBB26C, 229 pages, it costs $15.37 on US Amazon. Click here to order it from Amazon.com.
Audio – Publisher : Princeton University Press (September 19, 2023), ASIN : B0CF6WHBVX, listening length 7 hours, narrator : Christopher Ragland, it costs $0.99 on US Amazon. Click here to order it from Amazon.com.
Front cover of Elemental. Click on the image to go to the Amazon page for the hardcover version of the book.
Amazon’s description of the book
It is rare for life to change Earth, yet three organisms have profoundly transformed our planet over the long course of its history. Elemental reveals how microbes, plants, and people used the fundamental building blocks of life to alter the climate, and with it, the trajectory of life on Earth in the past, present, and future.
Taking readers from the deep geologic past to our current era of human dominance, Stephen Porder focuses on five of life’s essential elements—hydrogen, oxygen, carbon, nitrogen, and phosphorus. He describes how single-celled cyanobacteria and plants harnessed them to wildly proliferate across the oceans and the land, only to eventually precipitate environmental catastrophes.
He then brings us to the present, and shows how these elements underpin the success of human civilization, and how their mismanagement threatens similarly catastrophic unintended consequences. But, Porder argues, if we can learn from our world-changing predecessors, we can construct a more sustainable future.
Blending conversational storytelling with the latest science, Porder takes us deep into the Amazon, across fresh lava flows in Hawaii, and to the cornfields of the American Midwest to illuminate a potential path to sustainability, informed by the constraints imposed by life’s essential elements and the four-billion-year history of life on Earth.
The Story of HOCNP the Five Elements Essential to all Life
The author, a biogeochemist, explains why five elements, hydrogen (H), oxygen (O), carbon (C), nitrogen (N), and phosphorus (P) are essential to all life. As an example, in the sunlit waters of the central equatorial Pacific Ocean, a lack of Nitrogen creates a water desert with no life. Lifeforms that are able extract more of these elements have a competitive advantage.
This book focuses on three world-changing organisms that were able to extract unprecedented amounts of these elements from the environment also resulting in success and huge increases in the total mass of lifeforms, as well as consequences causing mass extinction eventually followed by an entirely new planet. Note this book is not about mass extinctions, which have happened at least five times, but something more profound. It is about planet-changing events.
During the first two billion years of earth’s history there had been no oxygen in the environment; oxygen was always bound to some other atom, such as hydrogen in water. There was life back then but in the form of primitive bacteria using a primitive form of photosynthesis involving sulfur. Then came cyanobacteria which had invented a more effective form of photosynthesis, as well as a way of extracting nitrogen using a process called nitrogen fixation. The two-atom nitrogen in the air is nearly inert and very difficult to use. This made cyanobacteria extremely successful.
However, one consequence was that the carbon dioxide was largely removed from the atmosphere, while the atmosphere was filled up by oxygen, which is a byproduct of the new form of photosynthesis. Carbon dioxide is a greenhouse gas that warms the planet, something scientists had already figured out in the 1850’s. With much less carbon dioxide, the earth got very cold, and a snowball earth disaster followed. However, in the long run the oxygen paved the way for the existence of multicellular life and animals. The planet changed.
About 400 million years ago plants was a new type organism that was able to extract water (hydrogen and oxygen) from land as well as phosphorus. Their success led to another depletion of carbon dioxide causing another ice period, but they paved the way for life on land. The planet changed again. Now humans, the third type of organism, are extracting all five elements in unprecedented amounts causing global warming and other unintended consequences.
Unlike cyanobacteria and plants, we are not doing this to primarily extract nutrients but for transportation, heating and consumer products and we can control and predict the consequences of our actions.
As evidence for global warming / climate change the author discusses the temperature measurement records of various organizations (NOAA etc.). That is the smoking gun.
However, he also mentions things like the fact that the vast majority of glaciers in the world are retreating or disappearing and the fact that anyone above the age of 50 who comes from a northern climate (that would be me) can attest to the fact that winters have gotten noticeably shorter snow seasons and warmer summers. That is true and it is a good thing to mention because there are those who are quick to dismiss temperature records as big hoaxes.
The second part of his global warming discussion, the evidence that we humans are the cause of the current warming, leaves something out in my opinion. He explains why the various climate models provide incontrovertible evidence that the chief cause for the current global warming is our burning of fossil fuels, despite the models being far from perfect. I totally agree with that, but once again there are those who are not willing to accept climate models as solid evidence, and therefore you should mention other evidence as well, which he does not do.
Examples of evidence that we are the cause and that does not involve complex models would be, no known natural cause can explain the current warming, the upper troposphere is cooling while the lower troposphere is warming, the arctic is warming much faster than average, nights are warming much faster than days, etc. Those are things that would not happen if the cause was a hotter sun (which we also kept a record of) or an orbital cycle.
In addition, spectral analysis shows the cause to be the adding of greenhouse gases to the atmosphere, and various isotope studies show that the carbon emissions come from the burning of hundreds of millions of years old carbon. Why not mention that as well? I know all this is baked into the models, but simple explanations appear more convincing to many. I am not taking off a star for it, but I felt it was a missed opportunity.
One environmental threat that you don’t hear much about is the depletion of phosphorus. This is something that may be far into the future but something that seems impossible to solve once it arrives and could evolve into an enormous food crisis. This was certainly a unpleasant surprise to me.
The book explains many processes and concepts, biogeochemistry, primitive photosynthesis using sulfur, photosynthesis using water (cyanobacteria) and releasing oxygen, nitrogen fixation, endosymbiosis, how plants extract phosphorus from the ground, the evolution of plants, the slow carbon cycles, the fast carbon cycle, the effect of volcanoes on climate, respiration, why can trust certain aspects of climate models, nitrogen fixation, nitrogenase, the immense effect fertilizers have had on food production, the Haber-Bosch process, earth’s climate history, why phosphorus is both finite and irreplaceable, the danger to aquifers, how we have changed ecosystems, and more.
Despite that the author makes himself understood. He explains complex concepts, so they are easy to understand and connects them all in a logical way that makes a lot of sense. So don’t be afraid that the book will be difficult to read. You may just learn a lot.
The author considers climate change / global warming to be our most serious environmental challenge, but he offers a lot of suggestions for a way forward. He discusses a lot of interesting technological solutions. I think he may be a bit gloomier than necessary but overall, what he says is very insightful and somewhat hopeful.
Again, I was very impressed by the organization of the book. It is easy to create a mess when you try to connect a lot of different concepts and complex science into a logical narrative, but he was very successful. It was a delight to read this book, it was interesting and full of facts, which were new to me, and I think are very important. I learned a lot and I think it is a very well written page turner.
Back cover of Elemental. Click on the image to go to the Amazon page for the kindle version of the book.
Newstrade